Productivity improvement

Over the last 30 years, biomanufacturing productivity improvements and cost reductions have been a key enabler to bring more treatments profitably to more markets to benefit more patients. The improvements have been startling, with process improvements in the monoclonal antibody (mAb) sector contributing to published commercial cost of goods (COG)/g values decreasing from over $10,000 per gram to $1000s per gram in the 1980-90s, to $10s-100s per gram today (Farid et al. (2020) mAbs, 12:1).

Since our first Phorum in 2008, BioPhorum has been proud to play its part in this journey. But costs remain prohibitive for many patient pools, compared with small-molecule treatments. BioPhorum member companies tell us that further improvements are key to increase patient access and improve margins, supporting reinvestment in R&D. Furthermore, new advanced therapy medicinal product (ATMP) treatments are at the start of the productivity journey that mAbs were 30 years ago. There is so much still to achieve – so how are the next generation of improvements going to be realized?

Through BioPhorum’s unique facilitated collaborations, members work together to identify new approaches, drive industry best practice and benchmarks that deliver optimized operations in ways that a single company cannot. Being members of the collaboration enables them to be at the forefront of implementing such improvements, and to learn from each other; both what works, but also what doesn’t, helping speed up their ability to adopt.

Driving value from sharing real world experiences of adopting new technologies, digital innovation including in-line analytics, supply chain optimization and agility, mapping manufacturing processes for CGT – our Phorums and workstreams are full of examples of measurable impact and improvements that members have achieved. Our members tell us that BioPhorum workstreams are playing a key role in driving the next frontier of industry productivity improvement.

BioPhorum success stories

Fully implemented, this approach has the potential to save 2-3 manufacturing slots per year, in addition to reducing data requirements.

A risk-based scientific approach to qualifying replenishment working cell banks, an industry view
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Members reduced mycoplasma/virus testing time by 90% (from 30 days to two by implementing this best practice approach.

Alternative adventitious agent detection methods in biopharmaceuticals: A proposal for a structured best practice approach for their evaluation, validation, and implementation
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A biomanufacturer who implemented the toolkit identified 22 improvement projects across multiple sites resulting in estimated savings of ~$3m across 6 sites and >100 days of external consultancy saved per site per year.

Forecasting and supply planning: A best practice guide for the biopharmaceutical supply industry and assessment tool
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Advanced Therapy Medicinal Products

Advanced Therapy Medicinal Products support the quest for better and faster development of cell, gene and RNA therapies​ through connecting therapy developers, contract manufacturing, and testing organizations to gain an understanding and respond to the challenges faced by the advanced therapeutics industry.

Development Group

Development Group accelerates and improves the development process of biopharmaceutical medicines for the benefit of the patient. Replacing isolation with collaboration by providing a “safe” space where subject matter experts can work on sharing solutions and best practice on emerging industry trends, implementation of new technologies and common issues whilst ensuring their intellectual property and confidentiality is protected.

Drug Substance

Drug Substance advances excellence in drug substance manufacturing and testing, acting as an industry voice to accelerate technology adoption, implement post-approval change more rapidly and increase confidence in maintaining compliance.

Fill Finish

Fill Finish accelerates development and acceptance of sustainable world-class filling and packaging operations for drug product which meets the future needs of patients. Through innovative solutions resulting from the sharing of expertise, we can overcome common performance challenges and deliver on quality and regulatory compliance.

Information Technology

Information Technology accelerates digital maturity across the ​global pharmaceutical manufacturing industry.

Quality

BioPhorum Quality provides a dedicated, safe space for quality professionals from biomanufacturers and contract organizations to coalesce and enhance effective collaboration to address shared industry challenges.

Regulatory-CMC

Regulatory CMC brings leaders together who have a common goal – to improve access to medicines through innovation in the Regulatory ecosystem. It provides a dedicated space for strategic leadership and a coordinated industry voice, to move from divergence to convergence.

Supply Chain to Patient

Supply Chain to Patient transforms the performance of global pharmaceutical clinical and commercial outbound supply chains through industry collaboration by creating transparent patient-centric, resilient and agile E2E supply chains, that consistently deliver high-quality medicines ensuring an uninterrupted supply to patients.

Supply Partner

Supply Partner is a trusted advisory group and collaboration that is the engine for driving change across the global industry for all things relevant to the inbound supply chain. Addressing the challenges of complexity, resilience, cost, sustainability, and innovation.

Sustainability

Sustainability enables the industry’s transition to a low carbon, circular future – supporting members to improve patient health while respecting the planet. We activate multi-disciplinary teams drawn from our network to deliver environmental sustainability improvements across the value chain.

Technology Strategy

Technology Strategy acts as one voice of the industry to define strategy, accelerate technology transformation and support technology translation and adoption. With a purpose of enabling the future state of flexible, resilient, sustainable end-to-end biomanufacturing.

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An industry perspective on understanding AAV capsid content variants
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EXTERNAL-RESOURCE
An intercompany perspective on practical experiences of predicting, optimizing and analyzing high concentration biologic therapeutic formulations
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The Drug Substance 2.0 Strategic Value Framework
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BioPhorum’s holistic approach to container closure integrity
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Digital Plant Maturity Model 3.0
NEWS
Inaugural BioPhorum Quality face to face – get involved
PODCAST
The next step in building regulatory as a capability to enable strategic innovation across the BioPhorum community
PODCAST
Delivering a Cell and Gene Therapy Outbound Supply Chain Pathway for the Industry
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A vision for the biopharmaceutical industry’s inbound supply chain
NEWS
A major milestone – a harmonized approach to product carbon footprint data
Technology Roadmap V 2.0
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BioPhorum Technology Roadmapping roadmap vision 2.0

Publications

Documents including best practices, vision statements and peer reviewed papers to help you take value back to your business.

Webinars

Discussing all aspects of the biopharmaceutical industry, from digitization and knowledge management to raw materials, supply chain, sustainability and more. Learn from the perspectives of those at the forefront of the industry.

Podcasts

BioPhorum Connect is our podcast series that keeps you up to date with the latest news and trends in the biopharmaceutical industry. From experienced professionals to thought leaders, these podcasts bring you the insights and perspectives of experts from around the world.

Tools

A variety of resources including design tools and user requirement specifications to help you improve and streamline your business processes.

Benchmarks and Surveys

Research conducted among the BioPhorum membership providing evidence to support change and identify best practice.

Browse all

Access a variety of free tools and papers and other resources designed to provide you with up-to-date information and insights to help you make informed decisions and maximize your success. Access our resources today and start making improving and streamlining your business processes.

WEBINAR
Bioreactivity testing in single-use system biomanufacturing
WEBINAR
Bioreactivity testing in single-use system biomanufacturing
WEBINAR
Bioreactivity testing in single-use system biomanufacturing
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DOWNLOAD
Digital Plant Maturity Model 3.0
WEBINAR
Bioreactivity testing in single-use system biomanufacturing