<< Back to TRM Value Tracker 8 Biomanufacturers17 Supply Partners1 Innovation Hub ScopeDraftRequirementsDesignContentAuthoringFundingProposalTechnologydevelopment DeliverableAvailable Company BenefitWhen Development of specifications for buffer preparation systems that enable: Reduction in buffer prep footprint Reduction in buffer labor Reduction in buffer costs Reduction in buffer preparation time Implementation of buffer stock blending systems can greatly reduce the capital and operating costs of biotechnology facilities designed and built in the future. The technology will enable SU bags of less than 2000L to be used in place of large SS tanks (often over 12,000L), at a savings of perhaps ~$20MM to $50MM per facility built. Labor requirements will also be greatly reduced, and buffer preparation can be reduced from a 3 x 7 day operation to a 1 x 5 day operation in each facility. The technology may also enable the transition from a predominately SS facility common today to a predominately SU facility of the future, with a capital reduction of ~$100MM to >$300MM per facility built in the future. ↑ Flexibility ↓ Cost ↑ Speed Buffer is not a facility capacity bottleneck Minimal facility footprint <50% of process footprint Enable inline testing & release of buffers 50% reduction in number of buffers 50% reduction in volume of buffer per kg product Reduce buffer labor by 90% Buffer capital - operating costs reduced by 75% 2019 Open source collaborative technology development leveraging $1m funding for $150K cash/in kind contribution from 15 companies The Buffer Prep Team are collaborating with NIIMBL following acceptance of their funding proposal for a prototype of the team’s design to be built and tested at The University of Delaware. Test data will mitigate risk that the industry sees with new technologies and with the open source design will speed up adoption. SkidStart UpAutomationStart UpRecipeDevelopmentExecution ofExperimentalPlans Slide last updated : 22nd March 2019 Submit a Comment Cancel reply Your e-mail address will not be published. Required fields are marked *Comment Name * Email * Website Save my name, e-mail, and website in this browser for the next time I comment. This site uses Akismet to reduce spam. Learn how your comment data is processed.