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DeliverableAvailable Company BenefitWhen
Development of specifications
for buffer preparation systems
that enable:

  • Reduction in buffer prep footprint

  • Reduction in buffer labor

  • Reduction in buffer costs

  • Reduction in buffer preparation time

Implementation of buffer stock blending systems can greatly reduce the capital and operating costs of biotechnology facilities designed and built in the future. The technology will enable SU bags of less than 2000L to be used in place of large SS tanks (often over 12,000L), at a savings of perhaps ~$20MM to $50MM per facility built. Labor requirements will also be greatly reduced, and buffer preparation can be reduced from a 3 x 7 day operation to a 1 x 5 day operation in each facility. The technology may also enable the transition from a predominately SS facility common today to a predominately SU facility of the future, with a capital reduction of ~$100MM to >$300MM per facility built in the future.

↑ Flexibility

↓ Cost


  • Buffer is not a facility capacity bottleneck

  • Minimal facility footprint <50% of process footprint

  • Enable inline testing & release of buffers

  • 50% reduction in number of buffers

  • 50% reduction in volume of buffer per kg product

  • Reduce buffer labor by 90%

  • Buffer capital - operating costs reduced by 75%


Open source collaborative technology development leveraging $1m funding for $150K cash/in kind contribution from 15 companies

The Buffer Prep Team are collaborating with NIIMBL following acceptance of their funding proposal for a prototype of the team’s design to be built and tested at The University of Delaware. Test data will mitigate risk that the industry sees with new technologies and with the open source design will speed up adoption.

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Slide last updated : 22nd March 2019

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