To understand industry approaches for developing high-concentration formulations, BioPhorum Development Group Formulation workstream conducted an inter-company collaborative exercise which included several surveys. This collaboration provided an industry perspective, experience, and insight into the practicalities for developing high-concentration biologics.
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Ultra high concentration formulation
May 2022 | Benchmarking, Deliverable, Deliverables Report, Development Group, Formulation and Drug Product Development
This member only survey covers the challenges of working with ultra-high concentration formulations, including; low dose volume products, viscosity aspects related to manufacturing and delivery, manufacturing and filling, automated screening, analytical challenges, osmolality considerations (hyper and hypo), syringeability, acceptable injection forces.