A BioPhorum member survey to gather preliminary information from across the biopharmaceutical industry on the characterization and risk assessment of HCP using mass spectrometry.
Host cell protein
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Enzymatic activity assays – general usage assessment
Nov 2022 | Benchmarking, Deliverable, Deliverables Report, Development Group, Host Cell Proteins and other Bioresidual Impurities
A BioPhorum member only survey to share knowledge into how, why and when enzymatic activity assays are performed.
Host cell protein risk assessment- Where we are with BioPhorum cross-company collaboration and what we have learnt from an industry perspective?
May 2022 | Conference, Deliverable, Deliverables Report, Development Group, Host Cell Proteins and other Bioresidual Impurities
A presentation on cross-company collaborative work and learnings produced from an industry perspective on host cell protein risk assessment. The presentation included a history of the HCP workstream, previous publications, planned future work and publication plans.
“High-risk” host cell proteins (HCPs): A multi-company collaborative view
Sep 2021 | Deliverable, Development Group, Host Cell Protein, Publication
This database and paper provide a comprehensive review and list of potential problematic HCPs that could impact the safety, efficacy, and quality aspects of CHO-produced biologics during their development and manufacturing. They provide a reference on the best practice and control strategy for “high-risk” HCPs” in the biopharmaceutical industry.