Lyophilization: An industry perspective on the application of modeling to lyophilization process scale up and transfer

While freeze-drying modeling is well established and documented, the extent of its application to routine operations, including development and manufacture, has not yet been fully realized. A survey, conducted by  BioPhorum revealed that only a few companies use modeling for scale up and transfer. This paper outlines different applications of modeling to freeze-drying of biopharmaceutical products at commercial scale. It also signals the intent of  BioPhorum  to champion a wider adoption, and realize the full potential of modeling across the industry to standardize lyophilization practices, accelerate technology transfers and optimize operational performance


This deliverable has been published via the Americal Pharmaceutical Review website.

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