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Raw material variability and control of the supply chain are important issues for the biopharmaceutical industry. The industry is still at an early stage in the journey to align the supply base with biopharma’s requirements to improve patient well-being by assuring product safety and meeting ever-increasing regulatory demands. This requires increased understanding, monitoring and control of raw materials. Leading global Biopharmaceutical Manufacturers have been working together within the Biophorum Operations Group (BPOG) and collaborating to create an industry endorsed and supported guidance package.