Industry game changer in removing bottlenecks in manufacture.
Lack of standardization
During raw material transfer for buffer preparation, open processing requires a separate buffer prep area in the facility. Current buffer stock prep takes a significant amount of lead time and planning, which could be reduced by an automated solution with digital controls. There is a lack of standardization in buffer supply design. Stock solution selection (concentration & stock type) is not optimized to maximize the benefit of buffer stock blending. No guidance exists on how to best optimize (balance between minimizing volume of solutions vs standardizing concentrations used). The material handling approach is manual and labor intensive, with poor ergonomics and limited dust control
Biomanufacturers and suppliers collaborate
The collaborative approach of biomanufacturers and suppliers exploring the current state of the buffer preparation process with the goal of moving toward a lights-out (automated) closed system approach.
Q – Improved consistent, quality stock solutions that have a long shelf life to account for shipping/storage
$ – Reduction in non-value-adding activities, across the industry and supply base
$ – Facility footprint – more efficient use of high-cost areas within a facility (e.g., reduction in clean space area used)
S – Faster/adoption for BSB model
T – reduce facility bottlenecks
Buffer Preparation deliverables
More related workstreams
Our workstreams focus on the areas with the greatest impact across the industry. Led by science, our members are problem-solving today’s sustainability issues. By working with the regulatory governance community, they are also creating future-ready outcomes for the industry.
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