The BioPhorum Cybersecurity collaboration workstream, and more recently Community of Practice, works with end users and suppliers to establish effective tools, processes and methods that help the biopharmaceutical industry mitigate the increasing risk with ever increasing “digitalized” plants.

In these resource pages you will find a series of articles exploring various aspects of cybersecurity under the NIST framework headings of Identity, Protect, Detect, Respond and Recover.

As manufacturing plants become more digital, effective cybersecurity is essential to keep facilities operational.

What is driving the increase in cyber risk for manufacturing plants?

OT systems are described as legacy within IT systems nomenclature. The reason is that the lifecycle for an OT system could be in excess of 30 years, whereas IT system lifecycles typically range between three and five years. OT systems may not have updated security patches because, in some cases, the support for these older systems is not available. Thirty years ago, many of these OT systems only supported local processes at local manufacturing and distribution center sites. This helped to reduce the risk of a cyberattack because only the local plant would be impacted. Industry 4.0 has accelerated the digital transformation creating ‘smart factories’. These smart factories interconnect with several systems, creating an architecture where systems communicate with IT systems outside of the plant.

Better OT/IT working to improve risk assessment and to manage cybersecurity incidents

The goal of this team, as a commnuity of practice, is to share learning and develop best practices that ensure biopharma manufacturing plants are safer from cybersecurity incidents and attacks. Whilst currently a commnuity of practice, ideas for future deliverables will be proposed to the BioPhorum IT leaders for approval. Recently the team helped to create content for the Digital Plant Maturity Model (DPMM) v3 cybersecurity and operations tab.

Cybersecurity deliverables


Tabletop exercise to improve incident response

26 October, 2023
3.61 MB

Vulnerability management in manufacturing OT networks—are we playing whack-a-mole?

25 October, 2023
301.10 KB

Manufacturing patching practices: safeguarding the manufacturing environment

25 August, 2021
285.36 KB

Cyber Education Series: Guidance on how to write a disaster recovery playbook for the manufacturing environment

27 November, 2020
576.10 KB

Cyber security: A standard CMDB data model for pharmaceutical manufacturing shop floor systems

30 July, 2020
283.42 KB

Cyber Security Configuration management database use cases

22 May, 2020
242.37 KB

Cyber security: Boutique vulnerabilities

13 May, 2020
5.65 MB

Cyber security: Information technology vs operations technology – a BioPhorum article

6 May, 2020
237.42 KB

Cyber security: Digital plant resilience assessment tool

27 April, 2020
120.66 KB

More related workstreams

Our workstreams focus on the areas with the greatest impact across the industry. Led by science, our members are problem-solving today’s sustainability issues. By working with the regulatory governance community, they are also creating future-ready outcomes for the industry.

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Advanced Therapy Medicinal Products

Advanced Therapy Medicinal Products support the quest for better and faster development of cell, gene and RNA therapies​ through connecting therapy developers, contract manufacturing, and testing organizations to gain an understanding and respond to the challenges faced by the advanced therapeutics industry.

Development Group

Development Group accelerates and improves the development process of biopharmaceutical medicines for the benefit of the patient. Replacing isolation with collaboration by providing a “safe” space where subject matter experts can work on sharing solutions and best practice on emerging industry trends, implementation of new technologies and common issues whilst ensuring their intellectual property and confidentiality is protected.

Drug Substance

Drug Substance advances excellence in drug substance manufacturing and testing, acting as an industry voice to accelerate technology adoption, implement post-approval change more rapidly and increase confidence in maintaining compliance.

Fill Finish

Fill Finish accelerates development and acceptance of sustainable world-class filling and packaging operations for drug product which meets the future needs of patients. Through innovative solutions resulting from the sharing of expertise, we can overcome common performance challenges and deliver on quality and regulatory compliance.

Information Technology

Information Technology accelerates digital maturity across the ​global pharmaceutical manufacturing industry.


BioPhorum Quality provides a dedicated, safe space for quality professionals from biomanufacturers and contract organizations to coalesce and enhance effective collaboration to address shared industry challenges.


Regulatory CMC brings leaders together who have a common goal – to improve access to medicines through innovation in the Regulatory ecosystem. It provides a dedicated space for strategic leadership and a coordinated industry voice, to move from divergence to convergence.

Supply Chain to Patient

Supply Chain to Patient transforms the performance of global pharmaceutical clinical and commercial outbound supply chains through industry collaboration by creating transparent patient-centric, resilient and agile E2E supply chains, that consistently deliver high-quality medicines ensuring an uninterrupted supply to patients.

Supply Partner

Supply Partner is a trusted advisory group and collaboration that is the engine for driving change across the global industry for all things relevant to the inbound supply chain. Addressing the challenges of complexity, resilience, cost, sustainability, and innovation.


Sustainability enables the industry’s transition to a low carbon, circular future – supporting members to improve patient health while respecting the planet. We activate multi-disciplinary teams drawn from our network to deliver environmental sustainability improvements across the value chain.

Technology Strategy

Technology Strategy acts as one voice of the industry to define strategy, accelerate technology transformation and support technology translation and adoption. With a purpose of enabling the future state of flexible, resilient, sustainable end-to-end biomanufacturing.

An industry perspective on understanding AAV capsid content variants
Needle On Yellow Background
An intercompany perspective on practical experiences of predicting, optimizing and analyzing high concentration biologic therapeutic formulations
The Drug Substance 2.0 Strategic Value Framework
Coloured dots on teal, next to vial
BioPhorum’s holistic approach to container closure integrity
Magnifying glass over a tablet all coloured blue
Digital Plant Maturity Model 3.0
Investigation Digital Workstreams
Peer to peer practical guidance on remote inspections and audits
The next step in building regulatory as a capability to enable strategic innovation across the BioPhorum community
BioPhorum roundals on sugical gloves
A visionary strategic framework for future patient-centric outbound biopharmaceutical supply chains
DNA and Earth on blue background
A vision for the biopharmaceutical industry’s inbound supply chain
Lightbulb And Icons On Colourful Background
BioPhorum environmental sustainability roadmap 2022
Technology Roadmap V 2.0
BioPhorum Technology Roadmapping roadmap vision 2.0


Documents including best practices, vision statements and peer reviewed papers to help you take value back to your business.


Discussing all aspects of the biopharmaceutical industry, from digitization and knowledge management to raw materials, supply chain, sustainability and more. Learn from the perspectives of those at the forefront of the industry.


BioPhorum Connect is our podcast series that keeps you up to date with the latest news and trends in the biopharmaceutical industry. From experienced professionals to thought leaders, these podcasts bring you the insights and perspectives of experts from around the world.


A variety of resources including design tools and user requirement specifications to help you improve and streamline your business processes.

Benchmarks and Surveys

Research conducted among the BioPhorum membership providing evidence to support change and identify best practice.

Browse all

Access a variety of free tools and papers and other resources designed to provide you with up-to-date information and insights to help you make informed decisions and maximize your success. Access our resources today and start making improving and streamlining your business processes.

Bioreactivity testing in single-use system biomanufacturing
Bioreactivity testing in single-use system biomanufacturing
Bioreactivity testing in single-use system biomanufacturing
Magnifying glass over a tablet all coloured blue
Digital Plant Maturity Model 3.0
Bioreactivity testing in single-use system biomanufacturing